Effect of Condom Use on Per-act HSV-2 Transmission Risk in HIV-1, HSV-2-discordant Couples
نویسندگان
چکیده
منابع مشابه
Incident HSV-2 infections are common among HIV-1-discordant couples.
BACKGROUND The synergy between herpes simplex virus type 2 (HSV-2) and human immunodeficiency virus type 1 (HIV-1) is well known, but lack of knowledge about the epidemiology of HSV-2 acquisition in HIV-1-discordant couples hampers development of HSV-2 prevention interventions that could reduce HIV-1 transmission. METHODS HIV-1-discordant couples were enrolled in Nairobi, Kenya, and followed ...
متن کاملPrevalence and risk factors of HSV-1 and HSV-2 antibodies in European HIV infected women.
OBJECTIVES To investigate the prevalence and risk factors of HSV-1 and HSV-2 antibodies in HIV infected women and the association between recurrent genital ulcerations and HIV disease progression in HSV-2 positive women. METHODS The presence of HSV antibodies was tested in 276 of the 487 women participating in a European cohort study of HIV infected women. Prevalence rate ratios described the...
متن کاملCharacteristics of HIV-1 Discordant Couples Enrolled in a Trial of HSV-2 Suppression to Reduce HIV-1 Transmission: The Partners Study
BACKGROUND The Partners HSV-2/HIV-1 Transmission Study (Partners Study) is a phase III, placebo-controlled trial of daily acyclovir for genital herpes (HSV-2) suppression among HIV-1/HSV-2 co-infected persons to reduce HIV-1 transmission to their HIV-1 susceptible partners, which requires recruitment of HIV-1 serodiscordant heterosexual couples. We describe the baseline characteristics of this ...
متن کاملProbability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda.
BACKGROUND The probability of HIV-1 transmission per coital act in representative African populations is unknown. We aimed to calculate this probability overall, and to estimate how it is affected by various factors thought to influence infectivity. METHODS 174 monogamous couples, in which one partner was HIV-1 positive, were retrospectively identified from a population cohort in Rakai, Ugand...
متن کاملRisk of HIV transmission in discordant couples.
270 www.thelancet.com Vol 372 July 26, 2008 confi dent that there had been no breach of research integrity on the part of the authors, and that every eff ort had been made to achieve consensus on the submitted manuscript. The Lancet also sought advice from the Committee on Publication Ethics (COPE), who agreed with the journal’s suggestion to invite Phadke to write a Correspondence letter for p...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2015
ISSN: 1058-4838,1537-6591
DOI: 10.1093/cid/civ908